"The diagnosis of many of these patients, especially those with encephalitis, would have been missed if it were not for the prospective design of our study," said study co-leader Thais Armangue, from Sant Joan de Deu Children's Hospital at the University of Barcelona, in Spain. anti-MOG disease: recurrent clinical events of optic neuritis and/or TM with either a negative anti-aquaporin-4 (AQP4) antibody test or a positive. This new study suggests that testing for the MOG antibody could help identify the most beneficial treatment for some of these disorders, the study authors said. However, the best treatment approaches and long-term outcomes remain unclear. Over the last 10 years, research has shown that several demyelinating diseases are associated with the MOG-antibody biomarker, and that patients with these diseases often improve with immunotherapy. Until about 10 years ago, patients with these diseases were thought to have atypical forms of MS, and the prognosis and best treatment methods were unknown. This group of neurological disorders can mimic similar conditions like multiple sclerosis (MS), making them difficult to diagnose correctly. These include neuromyelitis optica spectrum disorders and encephalitis, which cause severe brain and nervous system symptoms such as vision loss, muscle weakness and loss of coordination and speech, the researchers said. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min. IHC staining of FFPE human glioma with MOG antibody at 1ug/ml. Expected molecular weight: 15-28 kDa depending on glycosylation level. The findings suggest that the MOG antibody is associated with more life-threatening autoimmune conditions than previously thought. Western blot testing of 1) rat brain and 2) mouse brain lysate with MOG antibody at 0.5ug/ml. Of the 116 children who tested positive for MOG antibodies and received appropriate treatment, 85% had complete or near-complete recovery, according to the study published Feb. MOG antibodies damage the protective covering (myelin sheath) that surrounds nerve fibers in the brain, optic nerves and spinal cord, which means that messages can't be passed along these nerves. The investigators identified the myelin oligodendrocyte glycoprotein (MOG) antibody in their study of 535 children with central nervous system demyelinating disorders and encephalitis. 12, 2020 (HealthDay News) - Researchers who have pinpointed an antibody linked to life-threatening autoimmune disorders in children say their discovery could lead to faster diagnosis and treatment of these patients.
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